Post-doctoral Research Fellow to join the Stem Cell and Neurogenesis Lab 

IRCCS San Raffaele Scientific Institute in Milan, Italy, is looking for a post-doctoral research fellow to join the Stem Cells and Neurogenesis headed by Dott. Vania Broccoli at the Division of Neuroscience. The project will focus on the validation of a new gene therapy approach for Ataxia Telangiectasia (A-T). This disease is one of the most common genetic ataxias and is caused by recessive mutations in the ATM gene which encodes for a kinase with prominent role in orchestrating response to DNA damage and other cell stress stimuli. The lab has developed a new methodology which, for the first time, creates the basis to rescue ATM gene expression providing an unprecedented opportunity to develop a gene therapy approach to treat neurological and peripheral symptoms with strong clinical potential. The candidate will integrate in a lab with strong multi-disciplinary interests, endowed in a very stimulating environment and passionate to apply novel gene editing tools for the cure of neuropathologies.

Main responsibilities:

• Optimize gene therapy vectors and delivery routes with translational relevance;
• Validate this therapeutic application in truly innovative cellular and animal models of the disease;
• Assess new neurological deficits in ATM cellular and animal models and their reversibility after gene therapy.

The candidate we are looking for has the following skills:

• PhD in neurobiology and laboratory research;
• Documented experience in molecular biology/genetics and/or functional brain studies (neuroelectrophysiology);
• Previous experience on mouse models of neurological diseases;
• Excellent knowledge of English, both written and spoken
• Excellent interpersonal skills and a collaborative and proactive attitude.

What we offer:

• Type of contract: Co.Co.Co.;
• Duration: 3 years;
• Place of work: IRCCS San Raffaele Hospital, Via Olgettina, number 60 - Milan (Italy).

At San Raffaele Scientific Institute, a world-renowned center of excellence for clinical and scientific activities, we believe that considering diversity and promoting an open and inclusive environment is crucial to our success. We are committed to ensure that equal employment opportunities are provided and based on merit without regard to age, religion, sex, disability, medical condition, sexual orientation, cultural and social backgrounds, gender identity or expression, national or ethnic origin, or any other legally recognized status entitled to protection under applicable laws. We offer attractive conditions and rewards appropriate to an internationally competitive research organization.