The collaboration between the Center for Omics Sciences (directed by Giovanni Tonon, MD, PhD) and a well-established pharmaceutical company has generated several pilot projects, with specific clinical needs, involving different units of IRCCS Ospedale San Raffaele. This partnership has the objective of developing a platform for single cell analysis, starting from human liquid or solid biopsies, taking advantage of new and advanced technologies, e.g. microfluidic devices, innovative automatic image-based sorting and cutting edge NGS instruments. The downstream single cell genome sequencing analysis can give specific ad-hoc information to patients, getting towards high precision and personalized medicine with clinical application in multiple fields.
A collaborative teamwork
The different projects are coordinated by the COSR (manager: Elvira Famulari, PhD) in an integrated framework, involving a team of experts in cellular, molecular and computational biology. The involvement of different medical areas with different clinical needs and the common goal of an innovative single cell analysis result in a truly multidisciplinary environment. Moreover, the team is based in a very dynamic, multidisciplinary, and internationally renowned research hospital, benefiting from daily close interactions with one of the largest and most active multi-omics centers in Italy.
The position we offer is dedicated to the project “Liquid biopsy and human bladder cancer”, in collaboration with the Urological Research Institute at Ospedale San Raffaele and coordinated by Dr. Massimo Alfano. The project allows the candidate to work hand in hand with the clinical environment, and develop a translational project with an immediate, direct impact on the clinics.
Who we are looking for:
We are looking for experts and strongly motivated staff scientists with a solid background in cell biology techniques and previous expertise in flow cytometry. The successful candidates will work with human liquid biopsies at the cellular and genomics level (cell culture, cell manipulation, nucleic acid extraction and quality control, and library preparation for genome sequencing).
- interaction with clinicians;
- dealing with patients’ blood samples;
- scientific discussions;
- internal scientific support for technological R&D and scientific data production.
- life science degree (Masters or PhD);
- written and spoken English;
- proven ability to work in a research laboratory both in autonomy and as part of a team.
- cell culture;
- flow cytometry;
- immunofluorescence and fluorescence microscopy;
- strong communication and interpersonal skills.
- DNA and RNA extraction and library prep;
- next Generation Sequencing.
- starting from May 2022, 1y contract - renewable;
- place of work: IRCCS Ospedale San Raffaele, via Olgettina, 60 - Milan, Italy.